Many RWE strategies fail long before formal payer or HTA review – due to poor framing, mis‑sequencing, unclear research questions, and false assumptions about what counts as ‘decision-relevant evidence’. This roundtable helps attendees stress‑test their evidence strategies against real access expectations.

Networking Discussion Questions:

• At what point in your organization does RWE most often become misaligned with payer or HTA decision needs – and why?
• How are teams distinguishing between evidence that is ‘interesting’, ‘publishable’ and ‘payable’?
• What are the most common misconceptions stakeholders still have about what payers and HTA bodies will accept from RWE and AI‑enabled studies?
• If you were forced to cut half of your current RWE or HEOR activity, what would you keep because it truly influences access decisions?